Guillain Barre Syndrome
Characteristics: Acute inflammatory demyelinating polyneuropathy It is a progressive ascending demyelinating disease of peripheral nervous system Disease process may progress from lung or GI infection (Campylobacter jejuni, Mycoplasma pneumoniae, CMV, EBV) It results in lower motor neuron paralysis Flaccid tendon reflex Organ involvement: Sudden onset of skeletal muscle paralysis or weakness Weakness begins at the legs and spread at the cephalic direction Symmetrical involvement Involves trunk, arms, face Cranial nerve involvement: Oculomotor nerves (CN III, IV, VI): diplopia Facial nerve (CN VII): bilateral facial weakness Bulbar nerves (CN IX and X): dysphagia and dysarthria Hypoglossal nerve (CN XII): tongue weakness Intercostal muscle paralysis ➔ inadequate ventilation Diaphragm palsy Sensory symptoms (numbness, tingling, pain) may also be present, but they are often less prominent. Sensory abnormality may precede the motor weakness Associated with pain Autonomic