Blood supply of liver 25% of cardiac output, 1.5 L/ min Blood supply by hepatic artery (1/3 supply, 98% O2 saturation) and hepatic portal vein (2/3 supply, 70 - 85% O2 saturation) The hepatic triad is formed by the branches of the hepatic artery, hepatic portal vein and bile canaliculus which run together Portal venue and hepatic arteriole join together to form hepatic sinusoid (specialised capillary system) which optimises exchange with hepatocyte Venous drainage to IVC via right and left hepatic vein Regulation of hepatic blood flow Hepatic artery - extrinsic and intrinsic regulation mechanism Portal vein - extrinsic regulation mechanism Intrinsic mechanism: Myogenic autoregulation 👉🏻 if drop-in hepatic arterial pressure ➡️ flow is maintained by a decrease in hepatic arterial resistance Hepatic arterial buffer response 👉🏻 if reduction of flow in portal vein ➡️ compensatory decrease in resistance of hepatic artery t...
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